MSE proves to be inaccurate in short time series analysis, significantly losing its sensitivity. To overcome these limitations, some approaches propose different coarse-graining procedures and entropy estimation. Composite MSE (CMSE), refined composite MSE (RCMSE), and modified MSE (MMSE) are important examples. Multiscale fuzzy entropy (MFE) uses a fuzzy membership function to identify similarities between patterns within time series, avoiding zero counts or numeric instabilities in entropy calculation. Heart rate variability (HRV) series from rats and humans were obtained from previous studies. The first group of ECG data was recorded in 18 healthy Wistar rats. The recordings were performed in the Cardiovascular Physiology Laboratory of Ribeirão Preto Medical Schools, University of São Paulo. Briefly, the rats had their ECG recorded for approximately 1 h (40 to 80 min) at baseline conditions. Computer software (LabChart, ADInstruments, Sydney, Australia) was used to create RR series from ECG recordings, sampled at 2 kHz.
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